BAIT

CCNF

FBX1, FBXO1

cyclin F

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]

negative regulation of centrosome duplication [IDA]

protein ubiquitination [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

SCF ubiquitin ligase complex [IDA]

centriole [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

YWHAB

GW128, HEL-S-1, HS1, KCIP-1, YWHAA, RP1-148E22.1

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

GO Process (22)

GO Function (6)

GO Component (7)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

MAPK cascade [TAS]

RNA metabolic process [TAS]

Ras protein signal transduction [TAS]

activation of MAPKK activity [TAS]

apoptotic process [TAS]

axon guidance [TAS]

cytoplasmic sequestering of protein [IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

hippo signaling [TAS]

innate immune response [TAS]

insulin receptor signaling pathway [TAS]

intrinsic apoptotic signaling pathway [TAS]

mRNA metabolic process [TAS]

membrane organization [TAS]

negative regulation of protein dephosphorylation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

positive regulation of catalytic activity [IDA]

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]

small GTPase mediated signal transduction [TAS]

Gene Ontology Molecular Function

enzyme binding [IPI]
histone deacetylase binding [IPI]
phosphoprotein binding [IPI]
phosphoserine binding [IPI]
protein binding [IPI]
protein domain specific binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoplasmic vesicle membrane [TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

perinuclear region of cytoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ALS-linked loss of Cyclin-F function affects HSP90.

Siebert A, Gattringer V, Weishaupt JH, Behrends C

The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]

Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CCNF YWHAB	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Rayner SL (2021)	High	2.384	BioGRID	3305219

Curated By

BioGRID