BAIT
ACVR1
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
activin A receptor, type I
GO Process (22)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- G1/S transition of mitotic cell cycle [IMP]
- activin receptor signaling pathway [IDA]
- atrial septum primum morphogenesis [IMP]
- cardiac muscle cell fate commitment [IMP]
- embryonic heart tube morphogenesis [IMP]
- endocardial cushion cell fate commitment [IMP]
- mitral valve morphogenesis [IMP]
- negative regulation of activin receptor signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of signal transduction [IMP]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of ossification [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CANX
CNX, IP90, P90
calnexin
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.
Dynamic changes in protein-protein interaction (PPI) networks underlie all physiological cellular functions and drive devastating human diseases. Profiling PPI networks can, therefore, provide critical insight into disease mechanisms and identify new drug targets. Kinases are regulatory nodes in many PPI networks; yet, facile methods to systematically study kinase interactome dynamics are lacking. We describe kinobead competition and correlation analysis (kiCCA), ... [more]
Mol Cell Mar. 02, 2023; 83(5);803-818.e8 [Pubmed: 36736316]
Quantitative Score
- 0.796851834 [kiCCA Pearson R Value]
Throughput
- High Throughput
Additional Notes
- A kinobead competition and correlation analysis (kiCCA) involving a quantitative mass spectrometry-based chemoproteomic method was carried out to identify endogenous kinase interactors.
- High confidence interactions had a kiCCA Pearson R Value >=0.6.
Curated By
- BioGRID