BAIT
CBR1
CBR, SDR21C1, hCBR1
carbonyl reductase 1
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PAX6
AN, AN2, D11S812E, FVH1, MGDA, WAGR
paired box 6
GO Process (17)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- blood vessel development [IMP]
- central nervous system development [TAS]
- cornea development in camera-type eye [IMP]
- eye development [TAS]
- glucose homeostasis [IMP]
- iris morphogenesis [IMP]
- negative regulation of neurogenesis [ISS]
- neuron fate commitment [NAS]
- organ morphogenesis [TAS]
- pancreatic A cell development [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein ubiquitination [ISS]
- response to wounding [IEP]
- transcription from RNA polymerase II promoter [IMP]
- visual perception [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID