BAIT

NUP184

SPAP27G11.10c
nucleoporin Nup184
GO Process (3)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

RAE1

cut21, SPBC16A3.05c
RNA export factor, nucleoporin Rae1
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Regulation of mRNA export by nutritional status in fission yeast.

Whalen WA, Yoon JH, Shen R, Dhar R

We have isolated a mutation in nup184(nup184-1) that is synthetically lethal with the mRNA export defective rae1-167 mutation in Schizosaccharomyces pombe. The consequence of the synthetic lethality is a defect in mRNA export. The predicted Nup184p is similar to Nup188p of Saccharomyces cerevisiae, and a Nup184p-GFP fusion localizes to the nuclear periphery in a punctate pattern. The Deltanup184 null mutant ... [more]

Genetics Jul. 01, 1999; 152(3);827-38 [Pubmed: 10388805]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RAE1 NUP184
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247572
RAE1 NUP184
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247404

Curated By

  • BioGRID