RTT107
Gene Ontology Biological Process
Gene Ontology Cellular Component
BRE1
Gene Ontology Biological Process
- chromatin silencing at telomere [IMP]
- double-strand break repair via homologous recombination [IGI]
- histone monoubiquitination [IMP]
- histone ubiquitination [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic G1 DNA damage checkpoint [IMP]
- regulation of DNA-dependent DNA replication initiation [IMP]
- telomere maintenance via recombination [IGI]
- transcription from RNA polymerase II promoter [IGI, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Loss of H3 K79 trimethylation leads to suppression of RTT107-dependent DNA damage sensitivity through the translesion synthesis pathway.
Genomic integrity is maintained by the coordinated interaction of many DNA damage response pathways, including checkpoints, DNA repair processes, and cell cycle restart. In Saccharomyces cerevisiae,, the BRCT domain-containing protein Rtt107/Esc4 is required for restart of DNA replication after successful repair of DNA damage, and for cellular resistance to DNA damaging agents. Rtt107 and its interaction partner Slx4 are phosphorylated ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- double mutants show decreased sensitivity to MMS (PubCHEM ID: 4156 CHEBI ID: 25255)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RTT107 BRE1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 938888 |
Curated By
- BioGRID