GLP-1
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell fate specification [IGI]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic pattern specification [IGI, IMP]
- maintenance of dauer [IGI]
- nematode larval development [IGI, IMP]
- pharyngeal muscle development [IGI, IMP]
- regulation of cell proliferation [IMP]
- regulation of meiosis [IMP]
- reproduction [IMP]
Gene Ontology Cellular Component
SEL-12
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [NAS]
- amyloid precursor protein catabolic process [IBA]
- apical protein localization [IDA]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- cell fate specification [IMP]
- detection of temperature stimulus [IMP]
- membrane protein ectodomain proteolysis [IBA]
- negative regulation of apoptotic process [IBA]
- nervous system development [IMP]
- oviposition [IMP]
- positive regulation of Notch signaling pathway [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- growth cone [IBA]
- integral component of plasma membrane [IBA]
- lysosomal membrane [IBA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nucleus [IBA]
- perinuclear region of cytoplasm [IDA]
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
Quantitative Score
- 2.75 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SEL-12 GLP-1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | High | - | BioGRID | 467394 |
Curated By
- BioGRID