BAIT
SMAD2
7120426M23Rik, Madh2, Madr2, Smad-2, mMad2
SMAD family member 2
GO Process (45)
GO Function (20)
GO Component (9)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [IMP]
- cell fate commitment [IMP]
- common-partner SMAD protein phosphorylation [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- endoderm formation [IMP]
- gastrulation [IGI]
- heart development [IGI]
- in utero embryonic development [IGI, IMP]
- insulin secretion [IGI]
- intracellular signal transduction [IDA, ISO]
- lung development [IGI]
- mesoderm formation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nodal signaling pathway [ISO]
- organ growth [IGI]
- palate development [IMP]
- pancreas development [IGI]
- paraxial mesoderm morphogenesis [IMP]
- pattern specification process [IGI]
- pericardium development [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- post-embryonic development [IGI]
- protein phosphorylation [IDA, ISS]
- regulation of binding [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- response to cholesterol [ISO]
- response to glucose [IGI]
- signal transduction involved in regulation of gene expression [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, IGI, ISO]
- zygotic specification of dorsal/ventral axis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
MECOM
D630039M04Rik, Evi-1, Evi1, Jbo, Mds, Mds1, Mds1-Evi1, Prdm3, Znfpr1b1
MDS1 and EVI1 complex locus
GO Process (12)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- forebrain development [IMP]
- in utero embryonic development [IMP]
- inflammatory response [IMP]
- neutrophil homeostasis [IMP]
- pericardium development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- post-embryonic development [IMP]
- regulation of cell proliferation [IMP]
- renal system development [IGI]
- response to bacterium [IMP]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
Smads, key effectors of transforming growth factor (TGF)-beta, activin, and bone morphogenetic protein (BMP) signaling, regulate gene expression and interact with coactivators and corepressors that modulate Smad activity. The corepressor Evi-1 exerts its oncogenic effects by repressing TGF-beta/Smad3-mediated transcription, thereby blocking TGF-beta-induced growth arrest. Because Evi-1 interacts with the highly conserved MH2 domain of Smad3, we investigated the physical and ... [more]
J. Biol. Chem. Jun. 24, 2005; 280(25);24227-37 [Pubmed: 15849193]
Throughput
- Low Throughput
Curated By
- BioGRID