SIT4
Gene Ontology Biological Process
- DNA repair [IMP]
- G1/S transition of mitotic cell cycle [IGI]
- TOR signaling [IMP]
- actin cytoskeleton organization [IMP]
- cellular response to oxidative stress [IMP]
- dephosphorylation [IMP]
- fungal-type cell wall organization [IMP]
- intracellular signal transduction [IMP]
- replicative cell aging [IMP]
- tRNA wobble uridine modification [IMP]
Gene Ontology Molecular Function
PPH21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.
Inactivation of HAL3 in the absence of SIT4 function leads to cell cycle arrest at the G(1)-S transition. To identify genes potentially involved in the control of this phase of the cell cycle, a screening for multicopy suppressors of a conditional sit4 hal3 mutant (strain JC002) has been developed. The screening yielded several genes known to perform key roles in ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression through the g1/s phase transition (APO:0000269)
Additional Notes
- genetic complex
- overexpression rescues the G1-S cell cycle blockage seen in a Sis2/Sit4 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SIT4 PPH21 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 479006 | |
| SIT4 PPH21 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 435579 | |
| SIT4 PPH21 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 1238183 | |
| PPH21 SIT4 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 1238185 |
Curated By
- BioGRID