BAIT
SIS2
HAL3, phosphopantothenoylcysteine decarboxylase complex subunit SIS2, L000001899, YKR072C
Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PPH22
PPH2, phosphoprotein phosphatase 2A catalytic subunit PPH22, L000001473, YDL188C
Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.
Inactivation of HAL3 in the absence of SIT4 function leads to cell cycle arrest at the G(1)-S transition. To identify genes potentially involved in the control of this phase of the cell cycle, a screening for multicopy suppressors of a conditional sit4 hal3 mutant (strain JC002) has been developed. The screening yielded several genes known to perform key roles in ... [more]
Yeast Jan. 30, 2003; 20(2);157-69 [Pubmed: 12518319]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression through the g1/s phase transition (APO:0000269)
Additional Notes
- genetic complex
- overexpression rescues the G1-S cell cycle blockage seen in a Sis2/Sit4 mutant
Curated By
- BioGRID