USF1
Gene Ontology Biological Process
- carbon catabolite regulation of transcription [TAS]
- cellular response to insulin stimulus [IDA]
- glucose homeostasis [TAS]
- late viral transcription [IDA]
- lipid homeostasis [ISS]
- negative regulation of fibrinolysis [IC]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter by glucose [IMP, ISS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase II promoter by glucose [IC]
- response to UV [ISS]
- response to hypoxia [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
HCFC1
Gene Ontology Biological Process
- chromatin organization [TAS]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of cell cycle [TAS]
- positive regulation of gene expression [IDA]
- protein stabilization [IDA]
- regulation of protein complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- release from viral latency [NAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IMP]
- chromatin binding [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IMP]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.
The insulator element at the 5' end of the chicken beta-globin locus acts as a barrier, protecting transgenes against silencing effects of adjacent heterochromatin. We showed earlier that the transcription factor USF1 binds within the insulator and that this site is important for generating in adjacent nucleosomes histone modifications associated with active chromatin and, by inference, with barrier function. To ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| USF1 HCFC1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 676737 |
Curated By
- BioGRID