PHO80
Gene Ontology Biological Process
- cellular metal ion homeostasis [IMP]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of protein localization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PHO84
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Regulation of Manganese Antioxidants by Nutrient Sensing Pathways in Saccharomyces cerevisiae.
In aerobic organisms, protection from oxidative damage involves the combined action of enzymatic and non-proteinaceous cellular factors that collectively remove harmful reactive oxygen species. One class of non- proteinaceous antioxidants includes small molecule complexes of manganese (Mn) that can scavenge superoxide anion radicals and provide a backup for superoxide dismutase enzymes. Such Mn-antioxidants have been identified in diverse organisms, however ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: metal resistance (APO:0000090)
- phenotype: vegetative growth (APO:0000106)
- phenotype: chemical compound accumulation (APO:0000095)
Additional Notes
- deletion of pho84 rescues the growth of pho80 mutants in the presence of manganese and blocks the accumulation of manganese
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO80 PHO84 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.37 | BioGRID | 413958 | |
| PHO80 PHO84 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 268237 | |
| PHO80 PHO84 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 437458 | |
| PHO80 PHO84 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 437460 | |
| PHO80 PHO84 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 268236 |
Curated By
- BioGRID