BAIT

CDK1

CDC2, CDC28A, P34CDC2
cyclin-dependent kinase 1
GO Process (46)
GO Function (5)
GO Component (11)

Gene Ontology Biological Process

Homo sapiens
PREY

SSBP1

Mt-SSB, SOSS-B1, SSBP, mtSSB
single-stranded DNA binding protein 1, mitochondrial
GO Process (1)
GO Function (3)
GO Component (4)
Homo sapiens

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.

Radulovic M, Crane E, Crawford M, Godovac-Zimmermann J, Yu VP

Cyclin-dependent kinase subunit (CKS) proteins interact with cyclin-dependent kinases (CDKs) with high affinity. Mammalian CKS1 and CKS2 bind CDK1 and CDK2 and partake in the control of cell cycle progression. We identified CKS-interacting proteins by affinity purification followed by mass spectrometry in the human lymphocytic cell line Ramos. Apart from known interactors, such as CDKs, we identified a novel CDK-dependent ... [more]

Mol. Cell Proteomics Jan. 01, 2010; 9(1);145-52 [Pubmed: 19786724]

Throughput

  • Low Throughput

Curated By

  • BioGRID