IPL1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- homologous chromosome segregation [IMP]
- meiotic sister chromatid segregation [IMP]
- mitotic DNA integrity checkpoint [IGI]
- mitotic spindle disassembly [IMP]
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IMP]
- positive regulation of spindle checkpoint [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cytokinesis [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BIM1
Gene Ontology Biological Process
- microtubule depolymerization [IMP]
- microtubule nucleation [IPI]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of microtubule depolymerization [IMP]
- nuclear migration along microtubule [IMP]
- positive regulation of microtubule polymerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Spatiotemporal regulation of ipl1/aurora activity by direct cdk1 phosphorylation.
Oscillating cyclin-dependent kinase 1 (Cdk1) activity is the major regulator of cell-cycle progression [1], whereas the Aurora B kinase, as part of the chromosome passenger complex (CPC), controls critical aspects of mitosis such as chromosome condensation and biorientation on the spindle [2]. How these kinases mechanistically coordinate their important functions is only partially understood. Here, using budding yeast, we identify ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112) [synthetic lethality (APO:0000183)]
Additional Notes
- figure S3C.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BIM1 IPL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| IPL1 BIM1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 336764 | |
| BIM1 IPL1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.6768 | BioGRID | 2039391 | |
| BIM1 IPL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| BIM1 IPL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| BIM1 IPL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 656970 | |
| IPL1 BIM1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 656977 | |
| IPL1 BIM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 353306 | |
| IPL1 BIM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| IPL1 BIM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| BIM1 IPL1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID