SKA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDC80
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IBA]
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- establishment of mitotic spindle orientation [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic sister chromatid segregation [TAS]
- mitotic spindle organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.
The KMN network (named according to the acronym for KNL1, Mis12, and Ndc80) and the more recently identified Ska complex (Ska1-3) have been shown to mediate kinetochore (KT)-microtubule (MT) attachments. How these two complexes cooperate to achieve stable end-on attachments remains unknown. In this paper, we show that Aurora B negatively regulates the localization of the Ska complex to KTs ... [more]
Throughput
- Low Throughput
Additional Notes
- figure S2C.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDC80 SKA1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 811712 |
Curated By
- BioGRID