NDC80
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IBA]
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- establishment of mitotic spindle orientation [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic sister chromatid segregation [TAS]
- mitotic spindle organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SKA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.
Chromosome segregation during mitosis requires chromosomes to undergo bipolar attachment on spindle microtubules (MTs) and subsequent silencing of the spindle checkpoint. Here, we describe the identification and characterisation of a novel spindle and kinetochore (KT)-associated complex that is required for timely anaphase onset. The complex comprises at least two proteins, termed Ska1 (Spindle and KT Associated 1) and Ska2. Ska1 ... [more]
Throughput
- Low Throughput
Additional Notes
- colocalization to kinetochores
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SKA1 NDC80 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 670318 |
Curated By
- BioGRID