A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.

Carnero E, Ribas JC, Garcia B, Duran A, Sanchez Y

The Schizosaccharomyces pombe mutant ehs1-1 mutant was isolated on the basis of its hypersensitivity to Echinocandin and Calcofluor White, which inhibit cell wall synthesis. The mutant shows a thermosensitive growth phenotype that is suppressed in the presence of an osmotic stabiliser. The mutant also showed other cell wall-associated phenotypes, such as enhanced sensitivity to enzymatic cell wall degradation and an ... [more]

Mol. Gen. Genet. Sep. 01, 2000; 264(1);173-83 [Pubmed: 11016847]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

ehs1-1 mutation only

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YAM8 PCK2	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Carnero E (2000)	Low	-	BioGRID	247771
PCK2 YAM8	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Carnero E (2000)	Low	-	BioGRID	796697

Curated By

BioGRID

Interaction Summary

YAM8

Gene Ontology Biological Process

Gene Ontology Molecular Function

stretch-activated, cation-selective, calcium channel activity [IGI]

Gene Ontology Cellular Component

PCK2