BAIT
RPD3
MOF6, REC3, SDI2, SDS6, histone deacetylase RPD3, L000001696, L000001603, YNL330C
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p
GO Process (19)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription during meiosis [IMP]
- negative regulation of transcription from RNA polymerase I promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, IPI]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- regulation of DNA-dependent DNA replication initiation [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IPI]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- replicative cell aging [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
ADR1
DNA-binding transcription factor ADR1, L000000050, YDR216W
Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
GO Process (10)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- cellular response to oleic acid [IPI]
- chromatin organization [IDA]
- chromatin organization involved in regulation of transcription [IGI, IMP, IPI]
- negative regulation of chromatin silencing [IDA]
- peroxisome organization [IMP]
- positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter by oleic acid [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IPI]
- TFIIB-class transcription factor binding [IDA]
- TFIID-class transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IPI]
- TFIIB-class transcription factor binding [IDA]
- TFIID-class transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Exploring the yeast acetylome using functional genomics.
Lysine acetylation is a dynamic posttranslational modification with a well-defined role in regulating histones. The impact of acetylation on other cellular functions remains relatively uncharacterized. We explored the budding yeast acetylome with a functional genomics approach, assessing the effects of gene overexpression in the absence of lysine deacetylases (KDACs). We generated a network of 463 synthetic dosage lethal (SDL) interactions ... [more]
Cell May. 11, 2012; 149(4);936-48 [Pubmed: 22579291]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: colony size (APO:0000063)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- High Throughput: colony size reduction greater than 20% relative to wild type
- Low Throughput: spot dilution assay
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADR1 RPD3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 256132 |
Curated By
- BioGRID