HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FER
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [IBA, ISS]
- Kit signaling pathway [ISS]
- actin cytoskeleton reorganization [ISS]
- cell adhesion [IBA]
- cell differentiation [IBA]
- cell proliferation [IMP]
- cell-cell adhesion mediated by cadherin [ISS]
- cellular response to insulin stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cellular response to reactive oxygen species [ISS]
- chemotaxis [IBA]
- cytokine-mediated signaling pathway [IMP]
- diapedesis [ISS]
- extracellular matrix-cell signaling [ISS]
- innate immune response [IBA]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [ISS]
- interleukin-6-mediated signaling pathway [IMP]
- intracellular signal transduction [TAS]
- microtubule cytoskeleton organization [IMP]
- mitotic cell cycle [IMP]
- negative regulation of mast cell activation involved in immune response [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISS, TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- regulation of lamellipodium assembly [IDA]
- regulation of mast cell degranulation [IBA]
- regulation of protein phosphorylation [ISS]
- response to lipopolysaccharide [ISS]
- response to platelet-derived growth factor [ISS]
- substrate adhesion-dependent cell spreading [ISS]
- tyrosine phosphorylation of Stat3 protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine, but determinants of client recognition by HSP90 have remained frustratingly elusive. We systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37. Unexpectedly, many more kinases than ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
FER HSP90AA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 20.9829 | BioGRID | 3481432 |
Curated By
- BioGRID