CACNA1A
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CACNB2
Gene Ontology Biological Process
- calcium ion import [ISO]
- calcium ion transmembrane transport [ISO]
- neuromuscular junction development [IBA]
- positive regulation of calcium ion transport [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of voltage-gated calcium channel activity [IBA]
- synaptic transmission [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.
We describe a cardiac muscle isoform of the voltage-dependent calcium channel alpha1 subunit, which corresponds to the rabbit ortholog of alpha1C-a (Cav1.2a). We also cloned smooth muscle isoforms alpha1C-b (Cav1.2b) and alpha1C-d (Cav1.2d). Differences among these three isoforms lie within the N-terminal region (exon 1A or 1B), the sixth transmembrane segment of domain I (exon 8A or 8B), and the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CACNA1A CACNB2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.98 | BioGRID | 2678383 | |
| CACNB2 CACNA1A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID