BAIT

PAN2

USP52

PAN2 poly(A) specific ribonuclease subunit

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (6)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

RNA metabolic process [TAS]

RNA phosphodiester bond hydrolysis, exonucleolytic [IDA, TAS]

gene expression [TAS]

mRNA metabolic process [TAS]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]

nuclear-transcribed mRNA poly(A) tail shortening [TAS]

Gene Ontology Molecular Function

3'-5'-exoribonuclease activity [IDA]
poly(A)-specific ribonuclease activity [IDA, TAS]
protein binding [IPI]

Gene Ontology Cellular Component

PAN complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HSP90AA1

EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2

heat shock protein 90kDa alpha (cytosolic), class A member 1

Alzheimer's Disease Project

Arachidonic Acid Pathway Project

GO Process (16)

GO Function (10)

GO Component (10)

Gene Ontology Molecular Function

ATP binding [TAS]
ATPase activity [IDA]
MHC class II protein complex binding [IDA]
TPR domain binding [IDA, TAS]
identical protein binding [IPI]
nitric-oxide synthase regulator activity [IDA]
nucleotide binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein homodimerization activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytosol [NAS, TAS]

endocytic vesicle lumen [TAS]

extracellular region [TAS]

extracellular vesicular exosome [IDA]

mitochondrion [IDA]

nucleoplasm [IDA]

plasma membrane [TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.

Bett JS, Ibrahim AF, Garg AK, Kelly V, Pedrioli P, Rocha S, Hay RT

HIF1A (hypoxia-inducible factor 1Î±) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we have identified the pseudo-DUB (deubiquitinating enzyme)/deadenylase USP52 (ubiquitin-specific protease 52)/PAN2 [poly(A) nuclease 2] ... [more]

Biochem. J. Apr. 15, 2013; 451(2);185-94 [Pubmed: 23398456]

Throughput

High Throughput

Ontology Terms

hek-293 cell (BTO:0000007)

Additional Notes

exogenous expression of bait

Curated By

BioGRID