CDC25
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
WIS1
Gene Ontology Biological Process
- G1 cell cycle arrest in response to nitrogen starvation [IMP]
- G1 to G0 transition [IMP]
- MAPK cascade [IDA]
- MAPK cascade in response to starvation [IMP]
- MAPK cascade involved in osmosensory signaling pathway [IMP]
- activation of MAPK activity [IDA]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of transcription factor import into nucleus in response to oxidative stress [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell shape involved in G1 to G0 transition [IMP]
- regulation of translation in response to stress [IMP]
- stress-activated MAPK cascade [IMP]
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.
The wis1+ gene encodes a newly identified mitotic control element in Schizosaccharomyces pombe. It was isolated by virtue of its interaction with the mitotic control genes cdc25, wee1 and win1. The wis1+ gene potentially encodes a 66 kDa protein with homology to the serine/threonine family of protein kinases. wis1+ plays an important role in the regulation of entry into mitosis, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- wis1 overexpression rescues temperature-sensitivity of wee1-50 cdc25-22 win1-1 triple mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC25 WIS1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | 882979 | |
| WIS1 CDC25 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 349445 | |
| CDC25 WIS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246373 | |
| CDC25 WIS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| WIS1 CDC25 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| CDC25 WIS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| CDC25 WIS1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | PomBase | - |
Curated By
- BioGRID