Activation of fatty acids by acyl-CoA synthetase enzymes is required for de novo lipid synthesis, fatty acid catabolism, and remodeling of biological membranes. Human long-chain acyl-CoA synthetase member 6, ASCL6, is a form present in the plasma membrane of cells. Splicing events affecting the amino-terminus and alternative motifs near the ATP-binding site generate different isoforms of ACSL6.Isoforms with different fatty ... [more]

BMC Biochem. May. 01, 2010; 11(0);18 [Pubmed: 20429931]

Throughput

Low Throughput

Additional Notes

ACSL6 isoforms dimerize in vitro

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ACSL6 ACSL6	Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.	Soupene E (2006)	Low	-	BioGRID	887748
ACSL6 ACSL6	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Soupene E (2006)	Low	-	BioGRID	887747
ACSL6 ACSL6	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Soupene E (2010)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

ACSL6

Gene Ontology Biological Process

Gene Ontology Molecular Function

enzyme binding [IPI]long-chain fatty acid-CoA ligase activity [IDA, NAS]protein homodimerization activity [IDA]

Gene Ontology Cellular Component