The formation of acyl-CoA by the action of acyl-CoA synthetases plays a crucial role in membrane lipid turnover, including the plasma membrane of erythrocytes. In human, five Acyl-CoA Synthetase Long-chain (ACSL) genes have been identified with as many as 3 different transcript variants for each.Acyl-CoA Synthetase Long-chain member 6 (ACSL6) is responsible for activation of long-chain fatty acids in erythrocytes. ... [more]

BMC Mol. Biol. Jul. 13, 2006; 7(0);21 [Pubmed: 16834775]

Throughput

Low Throughput

Additional Notes

ACSL6 isoforms appear as dimers on gel after purification from E. coli
Isoforms (Uniprot IDs): Q9UKU0-1 interacts with Q9UKU0-1
Isoforms (Uniprot IDs): Q9UKU0-7 interacts with Q9UKU0-7
Isoforms (Uniprot IDs): Q9UKU0-8 interacts with Q9UKU0-8

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ACSL6 ACSL6	Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.	Soupene E (2006)	Low	-	BioGRID	887748
ACSL6 ACSL6	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Soupene E (2010)	Low	-	BioGRID	886830
ACSL6 ACSL6	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Soupene E (2010)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

ACSL6

Gene Ontology Biological Process

Gene Ontology Molecular Function

enzyme binding [IPI]long-chain fatty acid-CoA ligase activity [IDA, NAS]protein homodimerization activity [IDA]

Gene Ontology Cellular Component