MYD88
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interleukin-17 production [ISS]
- positive regulation of interleukin-23 production [ISS]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to interleukin-1 [IMP]
- signal transduction [NAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SYK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adaptive immune response [IBA, ISS]
- blood coagulation [TAS]
- blood vessel morphogenesis [ISS]
- cell proliferation [TAS]
- cellular response to molecule of fungal origin [ISS]
- defense response to bacterium [ISS]
- inflammatory response [IBA]
- innate immune response [IBA, ISS, TAS]
- integrin-mediated signaling pathway [ISS, NAS]
- leukocyte activation involved in immune response [ISS]
- leukocyte cell-cell adhesion [IDA]
- lymph vessel development [ISS]
- macrophage activation involved in immune response [IBA, ISS]
- neutrophil activation involved in immune response [IBA, ISS]
- neutrophil chemotaxis [IDA]
- organ morphogenesis [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- platelet activation [TAS]
- positive regulation of B cell differentiation [IBA]
- positive regulation of alpha-beta T cell proliferation [IBA]
- positive regulation of bone resorption [ISS]
- positive regulation of cell adhesion mediated by integrin [IBA, ISS]
- positive regulation of mast cell degranulation [IBA]
- protein phosphorylation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of arachidonic acid secretion [ISS]
- regulation of neutrophil degranulation [ISS]
- regulation of phagocytosis [ISS]
- regulation of platelet activation [ISS]
- regulation of platelet aggregation [IBA, ISS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of superoxide anion generation [ISS]
- serotonin secretion by platelet [ISS]
- transcription factor import into nucleus [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3.
Toll-like receptors (TLRs) are a major family of pattern recognition receptors, and they play a crucial role in innate immune responses. Activation of TLR4 signaling at the plasma membrane by its ligand lipopolysaccharide (LPS) stimulates a proinflammatory pathway dependent on the E3 ubiquitin ligase TRAF6 (tumor necrosis factor receptor-associated factor 6) and the kinase TAK1 (transforming growth factor β-activated kinase ... [more]
Throughput
- Low Throughput
Ontology Terms
- cell type: hek-293t cell (BTO:0002181)
Curated By
- BioGRID