BAIT
GZMA
CTLA3, HFSP
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GO Process (7)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [TAS]
- immune response [TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of endodeoxyribonuclease activity [IDA]
- negative regulation of oxidoreductase activity [IDA]
- positive regulation of apoptotic process [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
The killer lymphocyte protease granzyme A (GzmA) triggers caspase-independent target cell death with morphological features of apoptosis. We previously showed that GzmA acts directly on mitochondria to generate reactive oxygen species (ROS) and disrupt the transmembrane potential (DeltaPsi(m)) but does not permeabilize the mitochondrial outer membrane. Mitochondrial damage is critical to GzmA-induced cell death since cells treated with superoxide scavengers ... [more]
Cell May. 16, 2008; 133(4);681-92 [Pubmed: 18485875]
Throughput
- Low Throughput
Curated By
- BioGRID