BAIT
PTGS2
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
GO Process (19)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to hypoxia [IEP]
- cyclooxygenase pathway [IDA, TAS]
- lipoxygenase pathway [TAS]
- positive regulation of brown fat cell differentiation [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of fever generation [ISS]
- positive regulation of fibroblast growth factor production [ISS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- positive regulation of platelet-derived growth factor production [ISS]
- positive regulation of prostaglandin biosynthetic process [NAS]
- positive regulation of transforming growth factor beta production [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- prostaglandin biosynthetic process [ISS, NAS]
- prostaglandin metabolic process [TAS]
- regulation of blood pressure [ISS]
- regulation of inflammatory response [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CASK
CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, RP11-540L11.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (7)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- cell adhesion [TAS]
- extracellular matrix organization [TAS]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cellular response to growth factor stimulus [IMP]
- negative regulation of keratinocyte proliferation [IMP]
- negative regulation of wound healing [IMP]
- nucleotide phosphorylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. ... [more]
Nat Commun Apr. 12, 2014; 5(0);3650 [Pubmed: 24722188]
Throughput
- High Throughput
Curated By
- BioGRID