RAD6
Gene Ontology Biological Process
- DNA-templated transcription, termination [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IGI]
- chromatin silencing at telomere [IMP]
- double-strand break repair via homologous recombination [IGI]
- error-free postreplication DNA repair [IGI]
- error-free translesion synthesis [IGI]
- error-prone translesion synthesis [IGI]
- histone monoubiquitination [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic G1 DNA damage checkpoint [IMP]
- protein monoubiquitination [IMP]
- protein polyubiquitination [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of dipeptide transport [IMP]
- telomere maintenance via recombination [IGI]
- transcription from RNA polymerase II promoter [IPI]
- ubiquitin-dependent protein catabolic process via the N-end rule pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POL30
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- error-free translesion synthesis [IGI]
- establishment of mitotic sister chromatid cohesion [IGI]
- lagging strand elongation [IDA, IPI]
- leading strand elongation [IDA]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- meiotic mismatch repair [IGI, IMP]
- mismatch repair [IGI, IMP, IPI]
- mitotic cell cycle [IGI]
- mitotic sister chromatid cohesion [IGI, IPI]
- nucleotide-excision repair [IMP]
- positive regulation of exodeoxyribonuclease activity [IDA]
- positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [IDA]
- postreplication repair [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae.
The Rad6-Rad18 ubiquitin-conjugating enzyme complex of Saccharomyces cerevisiae promotes replication through DNA lesions via three separate pathways that include translesion synthesis (TLS) by DNA polymerases zeta (Polzeta) and Poleta and postreplicational repair mediated by the Mms2-Ubc13 ubiquitin-conjugating enzyme and Rad5. Here we report our studies with a proliferating cell nuclear antigen (PCNA) mutation, pol30-119, which results from a change of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: uv resistance (APO:0000085)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- pol30-119 mutation
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD6 POL30 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.6341 | BioGRID | 224294 | |
| RAD6 POL30 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2384751 | |
| RAD6 POL30 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 255322 | |
| RAD6 POL30 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 428253 | |
| RAD6 POL30 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 1032879 |
Curated By
- BioGRID