SSD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SIT4
Gene Ontology Biological Process
- DNA repair [IMP]
- G1/S transition of mitotic cell cycle [IGI]
- TOR signaling [IMP]
- actin cytoskeleton organization [IMP]
- cellular response to oxidative stress [IMP]
- dephosphorylation [IMP]
- fungal-type cell wall organization [IMP]
- intracellular signal transduction [IMP]
- replicative cell aging [IMP]
- tRNA wobble uridine modification [IMP]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.
Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss of LAS1 function causes the cells to arrest as 80% ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SIT4 SSD1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155628 | |
SIT4 SSD1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 437261 | |
SIT4 SSD1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 160270 |
Curated By
- BioGRID