MEC1
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IMP]
- DNA recombination [IMP]
- DNA replication [IMP]
- histone phosphorylation [IGI, IMP]
- nucleobase-containing compound metabolic process [IGI]
- positive regulation of DNA-dependent DNA replication [IMP]
- reciprocal meiotic recombination [IMP]
- telomere maintenance [IDA]
- telomere maintenance via recombination [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
XRS2
Gene Ontology Biological Process
- base-excision repair [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- sporulation resulting in formation of a cellular spore [IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.
Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its function is critical for the primary step of DSB repair, whether by homologous recombination (HR) or non-homologous ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: ionizing radiation resistance (APO:0000194)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Figure 4
- gamma IR
- xrs2-SH rescues mec1 lethality
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MEC1 XRS2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.381 | BioGRID | 1961531 | |
| MEC1 XRS2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | - | |
| MEC1 XRS2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156360 | |
| XRS2 MEC1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 436139 | |
| MEC1 XRS2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 2652816 |
Curated By
- BioGRID