SOC-2
LET-60
Gene Ontology Biological Process
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IGI, IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IGI, IMP]
- oogenesis [IGI]
- positive regulation of Rap GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of vulval development [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell projection organization [IGI, IMP]
- reproduction [IGI, IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping in C. elegans using proteins involved in vulval development.
Protein interaction mapping using large-scale two-hybrid analysis has been proposed as a way to functionally annotate large numbers of uncharacterized proteins predicted by complete genome sequences. This approach was examined in Caenorhabditis elegans, starting with 27 proteins involved in vulval development. The resulting map reveals both known and new potential interactions and provides a functional annotation for approximately 100 uncharacterized ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LET-60 SOC-2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 1.3571 | BioGRID | 465963 | |
| SOC-2 LET-60 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| LET-60 SOC-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | WormBase | - | |
| LET-60 SOC-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | WormBase | - | |
| LET-60 SOC-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | WormBase | - |