LET-60
Gene Ontology Biological Process
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IGI, IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IGI, IMP]
- oogenesis [IGI]
- positive regulation of Rap GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of vulval development [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell projection organization [IGI, IMP]
- reproduction [IGI, IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOC-2
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears to act downstream of or in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LET-60 SOC-2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 1.3571 | BioGRID | 465963 | |
| SOC-2 LET-60 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| LET-60 SOC-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | WormBase | - | |
| LET-60 SOC-2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low/High | - | WormBase | - | |
| SOC-2 LET-60 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low/High | - | WormBase | - |