BAIT

ARO8

bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, L000003949, YGL202W
Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ARO9

aromatic-amino-acid:2-oxoglutarate transaminase, L000003950, YHR137W
Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

High levels of Tryptophan reduce cell wall or membrane stress tolerance in Saccharomyces cerevisiae.

Ohashi K, Chaleckis R

Tryptophan (Trp) is a proteinogenic aromatic amino acid, however, high levels of Trp are toxic in animals and yeast with unknown mechanisms. Previously, we suggested that aromatic aminotransferase Aro9 is important for excess Trp degradation. Besides, Schroeder and Ikui showed that aro9? is sensitive to membrane stress by sodium dodecyl sulfate. Therefore, Trp accumulation may reduce the cell wall or ... [more]

Biosci Biotechnol Biochem Aug. 13, 2021; (); [Pubmed: 34387321]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: osmotic stress resistance (APO:0000082)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Figure 4
  • sensitivity to SDS and Calcofluor White and Congo Red

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ARO9 ARO8
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2346549
ARO8 ARO9
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
326037
ARO9 ARO8
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
2346550
ARO8 ARO9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
483394

Curated By

  • BioGRID