BAIT

ARO8

bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, L000003949, YGL202W
Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ARO9

aromatic-amino-acid:2-oxoglutarate transaminase, L000003950, YHR137W
Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Optimized psilocybin production in tryptophan catabolism-repressed fungi.

Janevska S, Weiser S, Huang Y, Lin J, Hoefgen S, Jojic K, Barber AE, Schaefer T, Fricke J, Hoffmeister D, Regestein L, Valiante V, Kufs JE

The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental disorders such as therapy-refractory depression, alcohol use disorder and anorexia nervosa. Psilocybin has been designated a 'Breakthrough Therapy' by the US Food and Drug Administration, and therefore a sustainable production process must be established to meet future market demands. Here, ... [more]

Microb Biotechnol Nov. 01, 2024; 17(11);e70039 [Pubmed: 39487767]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: stress resistance (APO:0000080)

Additional Notes

  • aro8/ aro9 double mutation causes a growth defect in the presence of excess tryptophan

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ARO8 ARO9
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
3753003
ARO9 ARO8
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2346549
ARO8 ARO9
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
326037
ARO9 ARO8
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
2346550
ARO8 ARO9
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
3026230
ARO8 ARO9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
483394

Curated By

  • BioGRID