BAIT

ARO8

bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, L000003949, YGL202W
Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ARO9

aromatic-amino-acid:2-oxoglutarate transaminase, L000003950, YHR137W
Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Pirkov I, Norbeck J, Gustafsson L, Albers E

The methionine salvage pathway is universally used to regenerate methionine from 5'-methylthioadenosine, a byproduct of certain reactions involving S-adenosylmethionine. We identified and verified the genes encoding the enzymes of all steps in this cycle in a commonly used eukaryotic model system: the yeast Saccharomyces cerevisiae. The genes encoding 5'-methylthioribose-1-phosphate isomerase and 5'-methylthioribulose-1-phosphate dehydratase are herein named MRI1 and MDE1, respectively. ... [more]

FEBS J. Aug. 01, 2008; 275(16);4111-20 [Pubmed: 18625006]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: metabolism and growth (APO:0000094)

Additional Notes

  • aro8 aro9 double mutants do not exhibit any 4-methylthio-2-oxobutyrate (MOB)transaminase activity coupled with aromatic amino acids.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ARO9 ARO8
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2346549
ARO9 ARO8
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
2346550
ARO8 ARO9
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
3026230
ARO8 ARO9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
483394

Curated By

  • BioGRID