GAS6
Gene Ontology Biological Process
- B cell chemotaxis [IDA]
- activation of protein kinase B activity [ISS]
- apoptotic cell clearance [IDA]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [TAS]
- cell cycle arrest [TAS]
- cell migration [TAS]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to interferon-alpha [IDA]
- cellular response to vitamin K [IDA]
- dendritic cell differentiation [IEP]
- extracellular matrix assembly [ISS]
- fusion of virus membrane with host plasma membrane [IDA]
- hematopoietic stem cell migration to bone marrow [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of biomineral tissue development [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-6 secretion [IDA]
- negative regulation of oligodendrocyte apoptotic process [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of renal albumin absorption [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- peptidyl-serine phosphorylation [IDA]
- phagocytosis [IDA]
- platelet activation [TAS]
- platelet aggregation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of TOR signaling [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of dendritic cell chemotaxis [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of natural killer cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of protein export from nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of protein tyrosine kinase activity [IDA]
- post-translational protein modification [TAS]
- protein kinase B signaling [IDA]
- protein phosphorylation [IDA]
- protein targeting to plasma membrane [IDA]
- proteolysis [TAS]
- receptor-mediated virion attachment to host cell [IDA]
- signal transduction [IDA, TAS]
- viral entry into host cell [IDA]
- viral genome replication [IDA]
Gene Ontology Molecular Function- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
AXL
Gene Ontology Biological Process
- cell maturation [IEP]
- cellular response to interferon-alpha [IDA]
- cellular response to lipopolysaccharide [IDA]
- dendritic cell differentiation [IEP]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- peptidyl-tyrosine phosphorylation [TAS]
- phagocytosis [IDA]
- positive regulation of cytokine-mediated signaling pathway [IDA]
- positive regulation of natural killer cell differentiation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.
Axl, Sky, and Mer, members of an Axl/Sky receptor tyrosine kinase subfamily, are typified by the cell adhesion molecule-related extracellular domain. The product of growth arrest-specific gene 6 (Gas6), structurally homologous to the anticoagulant protein S, was recently identified as the ligand for Axl and Sky, but the ligand for Mer remained unknown. We have now obtained evidence that Gas6 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXL GAS6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 204 | BioGRID | 3481807 | |
| AXL GAS6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9824 | BioGRID | 3549058 |
Curated By
- BioGRID