AXL
Gene Ontology Biological Process
- cell maturation [IEP]
- cellular response to interferon-alpha [IDA]
- cellular response to lipopolysaccharide [IDA]
- dendritic cell differentiation [IEP]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- peptidyl-tyrosine phosphorylation [TAS]
- phagocytosis [IDA]
- positive regulation of cytokine-mediated signaling pathway [IDA]
- positive regulation of natural killer cell differentiation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GAS6
Gene Ontology Biological Process
- B cell chemotaxis [IDA]
- activation of protein kinase B activity [ISS]
- apoptotic cell clearance [IDA]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [TAS]
- cell cycle arrest [TAS]
- cell migration [TAS]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to interferon-alpha [IDA]
- cellular response to vitamin K [IDA]
- dendritic cell differentiation [IEP]
- extracellular matrix assembly [ISS]
- fusion of virus membrane with host plasma membrane [IDA]
- hematopoietic stem cell migration to bone marrow [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of biomineral tissue development [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-6 secretion [IDA]
- negative regulation of oligodendrocyte apoptotic process [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of renal albumin absorption [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- peptidyl-serine phosphorylation [IDA]
- phagocytosis [IDA]
- platelet activation [TAS]
- platelet aggregation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of TOR signaling [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of dendritic cell chemotaxis [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of natural killer cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of protein export from nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of protein tyrosine kinase activity [IDA]
- post-translational protein modification [TAS]
- protein kinase B signaling [IDA]
- protein phosphorylation [IDA]
- protein targeting to plasma membrane [IDA]
- proteolysis [TAS]
- receptor-mediated virion attachment to host cell [IDA]
- signal transduction [IDA, TAS]
- viral entry into host cell [IDA]
- viral genome replication [IDA]
Gene Ontology Molecular Function- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.
Dynamic changes in protein-protein interaction (PPI) networks underlie all physiological cellular functions and drive devastating human diseases. Profiling PPI networks can, therefore, provide critical insight into disease mechanisms and identify new drug targets. Kinases are regulatory nodes in many PPI networks; yet, facile methods to systematically study kinase interactome dynamics are lacking. We describe kinobead competition and correlation analysis (kiCCA), ... [more]
Quantitative Score
- 0.982375148 [kiCCA Pearson R Value]
Throughput
- High Throughput
Additional Notes
- A kinobead competition and correlation analysis (kiCCA) involving a quantitative mass spectrometry-based chemoproteomic method was carried out to identify endogenous kinase interactors.
- High confidence interactions had a kiCCA Pearson R Value >=0.6.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXL GAS6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 204 | BioGRID | 3481807 | |
| GAS6 AXL | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID