BAIT

PLK1

PLK, STPK13
polo-like kinase 1
GO Process (34)
GO Function (7)
GO Component (14)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

Pinder A, Loo D, Harrington B, Oakes V, Hill MM, Gabrielli B

Cell cycle progression from G2 phase into mitosis is regulated by a complex network of mechanisms, all of which finally control the timing of Cyclin B/CDK1 activation. PLK1 regulates a network of events that contribute to regulating G2/M phase progression. Here we have used a proteomics approach to identify proteins that specifically bind to the Polobox domain of PLK1. This ... [more]

Cell Signal Nov. 01, 2015; 27(11);2296-303 [Pubmed: 26291670]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PLK1 PRKDC
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High89.6364BioGRID
3482761

Curated By

  • BioGRID