CDC48
Gene Ontology Biological Process
- ER-associated misfolded protein catabolic process [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- SCF complex disassembly in response to cadmium stress [IMP]
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- endoplasmic reticulum membrane fusion [IMP]
- macroautophagy [IMP]
- mitochondria-associated ubiquitin-dependent protein catabolic process [IMP]
- mitotic spindle disassembly [IMP]
- nonfunctional rRNA decay [IMP]
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- piecemeal microautophagy of nucleus [IMP]
- positive regulation of histone H2B ubiquitination [IMP]
- positive regulation of protein localization to nucleus [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- retrograde protein transport, ER to cytosol [IMP]
- ribophagy [IMP]
- ribosome-associated ubiquitin-dependent protein catabolic process [IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex [IDA]
- Cdc48p-Npl4p-Vms1p AAA ATPase complex [IDA]
- Doa10p ubiquitin ligase complex [IDA]
- Hrd1p ubiquitin ligase ERAD-L complex [IDA]
- RQC complex [IDA]
- cytosol [IDA]
- cytosolic large ribosomal subunit [IDA]
- endoplasmic reticulum membrane [IDA]
- mating projection tip [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
SGS1
Gene Ontology Biological Process
- DNA double-strand break processing [IGI]
- DNA duplex unwinding [IDA]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IDA]
- cellular response to DNA damage stimulus [IMP]
- chromosome organization [IMP]
- double-strand break repair via homologous recombination [IGI, IMP]
- gene conversion at mating-type locus, DNA double-strand break processing [IGI]
- intra-S DNA damage checkpoint [IGI, IMP]
- meiotic DNA double-strand break processing [IGI]
- meiotic chromosome segregation [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic joint molecule formation [IGI]
- regulation of reciprocal meiotic recombination [IGI]
- replicative cell aging [IMP]
- telomere maintenance [IGI]
- telomere maintenance via recombination [IGI, IMP]
- telomeric 3' overhang formation [IGI]
Gene Ontology Molecular Function
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The genetic landscape of a cell.
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, ... [more]
Quantitative Score
- -0.2536 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- A Synthetic Genetic Array (SGA) analysis was carried out to quantitatively score genetic interactions based on fitness defects that were estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an SGA score of epsilon > 0.08 for positive interactions and epsilon < -0.08 for negative interactions, and a p-value < 0.05.
- YDL126C is an essential gene and therefore the temperature sensitive allele YDL126C_tsq208 was used in the experiment
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SGS1 CDC48 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2839 | BioGRID | 2062773 | |
| CDC48 SGS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.244 | BioGRID | 1965806 | |
| SGS1 CDC48 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 2898229 | |
| SGS1 CDC48 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | High | - | BioGRID | 2340613 | |
| SGS1 CDC48 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 2898323 | |
| SGS1 CDC48 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | 0.0156 | BioGRID | 822754 |
Curated By
- BioGRID